New SDS-Based Polyelectrolyte Multicore Nanocarriers for Paclitaxel Delivery—Synthesis, Characterization, and Activity against Breast Cancer Cells

The low distribution of hydrophobic anticancer drugs in patients is one the biggest limitations during conventional chemotherapy. SDS-based polyelectrolyte multicore nanocarriers (NCs) prepared according to layer by (LbL) procedure can release paclitaxel (PTX), and selectively kill cancer cells. Our main objective was verify antitumor properties PTX-loaded NCs examine whether drug encapsulated these retained its cytotoxic properties. cytotoxicity nanosystems tested on MCF-7 MDA-MB-231 tumour cells non-cancerous HMEC-1 cell line vitro. Confocal microscopy, spectrophotometry, spectrofluorimetry, flow cytometry, RT PCR techniques were used define typical hallmarks apoptosis. It demonstrated that PTX exhibited similar free drug, especially triple negative breast model. Moreover, SDS/PLL/PTX SDS/PLL/PGA/PTX significantly reduced DNA synthesis. In addition, triggered apoptosis upregulated transcription Bax, AIF, cytochrome-c, caspase-3 mRNA. data demonstrate novel coated with PLL or PLL/PGA are good candidates for delivering PTX. discoveries have prominent implications possible choice newly synthesized, different therapeutic applications.